When used illegally, pure amphetamines may be mixed with other substances—such as sugar, glucose, or bi-carb soda—that can be poisonous. This may cause collapsed veins, tetanus, abscesses, and damage to the heart, lungs, liver, and brain. Amphetamine users may also use other drugs inappropriately to manage the side effects of amphetamines. Benzodiazepines, for example, are anti-anxiety agents that may be used to help an individual sleep, but that can also be addictive. Seeking amphetamine addiction rehabilitation is an important step toward taking back control of your life and starting the process of recovery. It’s important to have an individualized addiction treatment plan that is based on a proper assessment by treatment professionals.14 This helps determine the appropriate level of care based on your needs and the severity of your addiction.
Amphetamine
Funding was provided by the National Drug and Alcohol Research Centre (University of New South Wales). Evidence effect persisted after adjustment for demographics (D), other substance use (O) and premorbid risk (P). E, Evidence supporting this finding based on cross-sectional associations among samples of drug users. The funders had no role in study design; in the collection, analysis, and interpretation of data; in the writing of the report, or https://ecosoberhouse.com/ in the decision to submit the paper for publication. We approached this report as a systematic review of the peer-reviewed literature, and present the methods and results in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement [22]. A comparison of the mean peak increases in systolic and diastolic blood pressure produced by intravenous versus oral administration of 50 mg lisdexamfetamine.
Criteria for considering studies for this review
When you’re addicted, you may continue using the drug despite the harm it causes. Prescription amphetamine drugs such as Adderall, Ritalin, and Dexedrine, are Schedule II drugs. While these can be abused, they can be helpful for attention deficit and other disorders. However, meth has a high potential for abuse, which can mean dangerous and fatal consequences. Meth is smoked, snorted, injected, and can reach the brain quickly, causing considerable damage.
Results of Individual Studies
Again, if disputes arose, these were resolved either by discussion between the two reviewers or the correspondence author of the paper. Therapy and medications are available to help you manage this chronic condition when you’re ready. After using a substance frequently, your body gets used to having it around all the time. Withdrawal happens when it leaves your body and the intoxication effects wear off.
- In this review, a valid scale means a scale that has been published in a scientific journal.
- Amphetamine’s isomers have long been known to be inhibitors of this important catabolising enzyme (Mantle et al., 1976; Miller et al., 1980; Robinson, 1985).
- Table 3 lists the pharmacotherapies reviewed, and the proposed mechanisms of action related to their use in studies of MA/AMPH dependence.
- MA is considered a more potent derivative of AMPH, with a longer duration of action and increased ability to cross the blood–brain barrier; and global shifts in the illicit stimulant market have resulted in the predominance of MA [2, 3].
- Three studies examined sustained/extended-release oral methylphenidate in addition to the study reporting methylphenidate versus aripiprazole discussed earlier.
Immediate effects
These changes to the brain mean that a person may always be at risk of using a substance again, even if they have not used it for a long time. An individual’s brain chemistry changes during regular misuse of a substance or activity. The brain’s reward circuit changes, reducing a person’s ability to exercise self-control and leading to strong urges to continue.